HOW TO CHOOSE THE RIGHT PARTICLE SIZE ANALYZER ?

Why Need to Invest in a Particle Size Analyzer ?

In pharmaceutical research and development (R&D), the pre-formulation stage is a critical starting point that defines the quality of the final product. At this stage, determining the particle size of raw materials is a cornerstone, directly impacting essential properties such as solubility, bioavailability, and drug stability. Investing in a particle size analyzer for raw materials in a pharmaceutical research lab is a pivotal decision that delivers numerous practical benefits, including:

Quality Control of Raw Materials: Particle size directly influences dissolution rate, bioavailability, and drug stability. Controlling raw material quality ensures that the final product meets the desired standards.
Ensuring Consistency of Raw Materials: A particle size analyzer enables monitoring of particle size variations across different batches, ensuring consistent quality in the final product.
Supporting New Formulation Development: Particle size affects properties like stability, absorption, and active ingredient release time. A particle size analyzer provides critical data to predict and control these factors, accelerating product development timelines.
Compliance with Regulations and Standards: Meeting stringent requirements from regulatory bodies such as the FDA and EMA, minimizes legal risks.
Long-term Cost Savings: By controlling raw material quality and optimizing production, waste is reduced, and costs associated with rework or product recalls due to defects are avoided, yielding cost efficiency despite the high initial investment.

However, in developing countries like Vietnam, many R&D labs face a significant challenge: how to access modern analytical equipment at a reasonable cost? With a multitude of options available on the market, how can users identify the most suitable device? Through this article, SEN Pharma aims to provide answers to these pressing questions.

Technologies to Consider When Investing in a Particle Size Analyzer

Particle size analyzers employ a variety of technologies, each with distinct advantages and limitations. Below is an overview of some key technologies:

Technology	Suitable Particle Shape	Particle Size Range *	Sample Form	Measurement Principle	Measured Parameters
Laser diffraction	Spherical	0.010 µm – 2000 µm	Dry powder or suspension	Scattering/diffraction of sample	Equivalent spherical diameter
Dynamic light scattering	Spherical	0.3 nm -10 μm	suspension **	Brownian motion	Hydrodynamic size
Particle Size and Shape Analyzer	All shapes	2 -3000 μm	suspension **	Image analysis	Equivalent spherical diameter, length, width, aspect ratio, etc.
SEM Microscopy	All shapes	> 10 nm	Dry powder ***	Image analysis	Diameter, width, length, aspect ratio, surface morphology
Sieve Analyzer	All shapes	30 µm – 120 mm	Dry powder	Weight	Amount of powder retained on each sieve

* These values are approximate, as the size range may vary depending on the manufacturer.

** Analysis is performed on suspensions. Dry powders can be dispersed in a suitable medium before analysis.

*** Suspension or wet samples can be dried to suit the SEM method.

Key Equipment Parameters to Consider from a User’s Perspective

Equipment Parameter to Consider	Benefit
Does the measurement range cover nanometers to millimeters ?	Ensures the device can measure particle sizes within the required range
Accuracy and repeatability between measurements	Provides reliable, consistent results critical for research and quality control.
Sample handling capability: large or small sample volume? Dry powder or liquid form ?	Measuring small sample volumes is vital for costly or scarce materials. Versatility in handling dry and wet samples meets diverse research needs.
Is the software interface user-friendly ?	An intuitive interface with robust data integration enhances efficiency and saves time.
Is the device easy to clean and maintain ?	Simplifies maintenance, extends equipment lifespan, and prevents cross-contamination for reliable results.
What is the after-sales service like ?	Prompt support resolves issues quickly, minimizing downtime, especially for imported equipment

Budget Constraints: What to Focus On ?

Small Labs with Limited Budgets: Prioritize compact, user-friendly, and cost-effective devices, even if they lack advanced features that may not be essential. For instance, if the focus is solely on solid dosage forms, there’s no need for equipment designed to measure suspensions or nano-sized particles…
Large Labs with Specialized Research: Invest in equipment with advanced, integrated features to support in-depth research requirements.

Contact SEN Pharma for Consultation

To find the particle size analyzer best suited to your needs and budget, reach out to SEN Pharma – a trusted partner in pharmaceutical research equipment and consultation. Our expert team is ready to offer detailed guidance and support throughout your selection process.

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